Objective to research the histopathological and hematological changes in reoperation of recurrent persistent rhinosinusitis with nasal polyps (CRSwNP). Techniques A total of 41 patients with CRSwNP who underwent two consecutive endoscopic sinus surgeries in Peking Union health College Hospital from February 1999 to April 2019 had been included retrospectively, including 25 males and 16 females, aged (40.7±13.6) many years during the previous surgery and (47.0±13.2) years during the recurrent surgery. The peripheral blood cellular count results had been collected. Differential inflammatory cells in nasal polyp muscle areas were counted and characteristics of muscle remodeling were scored. Paired t test had been used to compare the hematological and histological information associated with the two surgeries in the same cohort. Spearman’s ranking correlation coefficient had been made use of to look for the correlation between tissue and peripheral bloodstream eosinophil items. Results In histopathological tissue sections of nasal polyps, the mean structure eosinophil, lymphocyte and complete inflammatory cell matters per high power industry significantly decreased (54.ery. Conclusions In the recurrent surgery of CRSwNP, tissue eosinophil, lymphocyte and total inflammatory cell counts reduce significantly compare with compared to the former surgery. The histological inflammatory load decreases with enhancement of muscle remodeling, that could be related to the incorporated therapy with surgery and medications.Objective To explore the feasibility of repair of nasal tip with septal cartilage and auricular cartilage. Techniques From September 2018 to October 2019, 17 clients (two men and fifteen females) with reasonable noses underwent rhinoplasty under general anesthesia. Age the patients ranged from 19 to 39, with on average 27 yrs old. Among them, most of the 17 instances had been main rhinoplasty. Throughout the procedure, autologous nasal septum cartilage had been utilized as septal extension graft to extend the caudal septum, together with auricular cartilage ended up being used to boost the security of this strut and also to elevate the end for adjusting the shape of nose by making into spreader graft, columellar strut graft, derotation graft and onlay graft. The nasal dorsum was full of polytetrafluoroethylene. Digital scanning technology ended up being used to judge the nasal structure pre and post procedure. SPSS 22 software ended up being utilized to analyze the data with paired t-test. Results The follow-up ended up being from 6 to one year, with an avaerge of 7.6 months. Seventeen patients were pleased with postoperative nasal morphology and level. There was clearly no infection, prosthesis displacement, skin flap necrosis, no auricle deformation as well as other complications. Statistical software SPSS 22 performed paired t-test on the preoperative and postoperative data obtained by electronic technology postoperative nasal length and nasal tip protrusion enhanced compared with that before surgery, and it had been Mediator of paramutation1 (MOP1) statistically significant(length(3.60±0.77)mm, tip protrusion(3.61±0.64)mm, t worth was -19.203 and -23.132 correspondingly, both P less then 0.001). The nasolabial Angle was smaller than that before surgery, together with information had been statistically significant(3.40°±2.11°,t=6.635, P less then 0.001). Conclusion The nasal tip and nasal septum expansion complex built by autogenous nasal septal cartilage along with auricular cartilage can increase the length of nasal tip, increase the height of nasal tip and minimize the angle of nasolabial angle.Objective To investigate the variation of genetics connected with Usher syndrome kind see more 1(USH1)in 136 Chinese deafness families from Henan province. Practices the info of 136 deafness people tested by next-generation sequencing(NGS) which identified in the heart of genetics and prenatal analysis of this First Affiliated Hospital of Zhengzhou University from November 2016 to December 2019 had been analysized and the variation regularity of six genes related to Usher syndrome type 1(MYO7A, USH1C, CDH23, PCDH15, USH1G, CIB2) were summarized. Outcomes Five deafness families were detected nine pathogenic or most likely pathogenic variations in 2 genetics, accounting for 3.7% of all people. Included in this, four families had been caused by MYO7A variations and one family ended up being brought on by CDH23 variation. Meanwhile, seven variations of two genes had been reported for the first time. These were c.313delG, c.5257dupA, c.5435A>T, c.5636G>C, c.5722T>G of MYO7A, and c.155_166del, c.4802delA of CDH23. The customers’ eyesight of family members 2 and family members 3 had no apparent abnormality at present, but in accordance with hereditary diagnosis and walking dealy, they were regarded as being USH1. Conclusions MYO7A is considered the most common caustive gene connected with USH1 in Henan deafness clients, the effective use of next-generation sequencing technology makes USH1 patients diagnosed previously before the aesthetic signs appear.Objective To explore the end result of perioperative airway management based on the concept of improved data recovery after surgery (ERAS) on the enhancement of preoperative pulmonary function in patients with aspirin intolerance triad (AIT). Practices Thirty patients with AIT (including 13 guys and 17 females, elderly from 29 to 75 years old) for sinus surgery from January 2018 to December 2019 were selected, 172 patients (including 105 men and 67 females, elderly from 17 to 83 years old) with chronic rhinosinusitis with nasal polyps (CRSwNP) without reduced airway disease had been selected by random number table at the same duration, and their particular clinical data and preoperative pulmonary function had been examined and compared retrospectively. FEV1%pred less then 80% after bronchodilation test ended up being considered as high-risk for surgery. Preoperative evaluation and standardized medicine intervention were used in patients with pulmonary purpose abnormalities at risk for surgery, and improvement of preoperative pulmonary function and tolerabin the two groups before surgery were considerably enhanced compared to those at admission respectively Immune enhancement ((90.00±6.32)% vs. (64.79±13.60)%,t worth had been 10.110 in AIT group; (91.65±11.86)% vs. (76.40±9.35)%, t value was 9.346 in CRSwNP group; all P less then 0.05), also FEV1/FVC%pred, FEF50%pred, FEF75%pred and MMEF%pred were all significantly improved (all P less then 0.05). Operation had been finished successfully within the two sets of patients with lung function meeting the surgical standard, with no intraoperative or postoperative airway undesirable events occurred.
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